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ot ii thy1 1 mice  (Jackson Laboratory)

 
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    Jackson Laboratory ot ii thy1 1 mice
    a–d , Therapeutic effect of TGM1–IL-2 in DSS-induced colitis (PBS, n = 9 mice; TGM1–IL-2, n = 10 mice). a , Individual weight changes of mice in the indicated groups. b , Representative flow cytometry plots and quantification of IFN-γ + and IL-17a + CD4 + T-cell frequencies in the colon. c , Representative flow cytometry plots and quantification of Foxp3 + and Foxp3 <t>-</t> <t>Thy1.1</t> + OT-II cell frequencies among total CD4 + T cells in the indicated tissues. d , Representative flow cytometry plots and quantification of Rorγt + and Gata3 + cell frequencies among Foxp3 + OT-II cells in the indicated tissues. e , UMAP plots showing the indicated transcription factor activity scores across clusters. f , Venn diagram illustrating the overlap of up- and down-regulated DEGs between the indicated groups. DEGs were filtered using an adjusted p value < 0.0001 and log 2 fold change > 1. g , Gene regulatory networks and signature genes identified by scRNA-seq analysis. The two numbers in parentheses represent the specific values from the Venn diagram shown in Extended Data Fig. 12f (right). h , Schematic illustration of antigen-specific pTreg differentiation in vivo driven by TCR stimulation, TGM1–IL-2, and key transcription factors. Created in BioRender; Sun, Q. https://BioRender.com/2rbbpii (2026). Data are presented as mean ± s.e.m. The data in a–d are representative of two independent experiments. The statistics were obtained by unpaired Welch’s t-test (two-tailed) ( b and c ).
    Ot Ii Thy1 1 Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ot+ii+thy1+1+mice/pmc13190267-201-7-3?v=Jackson+Laboratory
    Average 86 stars, based on 1 article reviews
    ot ii thy1 1 mice - by Bioz Stars, 2026-06
    86/100 stars

    Images

    1) Product Images from "Facile induction of immune tolerance by an interleukin-2–TGFβ surrogate agonist"

    Article Title: Facile induction of immune tolerance by an interleukin-2–TGFβ surrogate agonist

    Journal: Nature

    doi: 10.1038/s41586-026-10208-0

    a–d , Therapeutic effect of TGM1–IL-2 in DSS-induced colitis (PBS, n = 9 mice; TGM1–IL-2, n = 10 mice). a , Individual weight changes of mice in the indicated groups. b , Representative flow cytometry plots and quantification of IFN-γ + and IL-17a + CD4 + T-cell frequencies in the colon. c , Representative flow cytometry plots and quantification of Foxp3 + and Foxp3 - Thy1.1 + OT-II cell frequencies among total CD4 + T cells in the indicated tissues. d , Representative flow cytometry plots and quantification of Rorγt + and Gata3 + cell frequencies among Foxp3 + OT-II cells in the indicated tissues. e , UMAP plots showing the indicated transcription factor activity scores across clusters. f , Venn diagram illustrating the overlap of up- and down-regulated DEGs between the indicated groups. DEGs were filtered using an adjusted p value < 0.0001 and log 2 fold change > 1. g , Gene regulatory networks and signature genes identified by scRNA-seq analysis. The two numbers in parentheses represent the specific values from the Venn diagram shown in Extended Data Fig. 12f (right). h , Schematic illustration of antigen-specific pTreg differentiation in vivo driven by TCR stimulation, TGM1–IL-2, and key transcription factors. Created in BioRender; Sun, Q. https://BioRender.com/2rbbpii (2026). Data are presented as mean ± s.e.m. The data in a–d are representative of two independent experiments. The statistics were obtained by unpaired Welch’s t-test (two-tailed) ( b and c ).
    Figure Legend Snippet: a–d , Therapeutic effect of TGM1–IL-2 in DSS-induced colitis (PBS, n = 9 mice; TGM1–IL-2, n = 10 mice). a , Individual weight changes of mice in the indicated groups. b , Representative flow cytometry plots and quantification of IFN-γ + and IL-17a + CD4 + T-cell frequencies in the colon. c , Representative flow cytometry plots and quantification of Foxp3 + and Foxp3 - Thy1.1 + OT-II cell frequencies among total CD4 + T cells in the indicated tissues. d , Representative flow cytometry plots and quantification of Rorγt + and Gata3 + cell frequencies among Foxp3 + OT-II cells in the indicated tissues. e , UMAP plots showing the indicated transcription factor activity scores across clusters. f , Venn diagram illustrating the overlap of up- and down-regulated DEGs between the indicated groups. DEGs were filtered using an adjusted p value < 0.0001 and log 2 fold change > 1. g , Gene regulatory networks and signature genes identified by scRNA-seq analysis. The two numbers in parentheses represent the specific values from the Venn diagram shown in Extended Data Fig. 12f (right). h , Schematic illustration of antigen-specific pTreg differentiation in vivo driven by TCR stimulation, TGM1–IL-2, and key transcription factors. Created in BioRender; Sun, Q. https://BioRender.com/2rbbpii (2026). Data are presented as mean ± s.e.m. The data in a–d are representative of two independent experiments. The statistics were obtained by unpaired Welch’s t-test (two-tailed) ( b and c ).

    Techniques Used: Flow Cytometry, Activity Assay, In Vivo, Two Tailed Test



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    ot ii thy1 1 mice  (Jackson Laboratory)
    86
    Jackson Laboratory ot ii thy1 1 mice
    a–d , Therapeutic effect of TGM1–IL-2 in DSS-induced colitis (PBS, n = 9 mice; TGM1–IL-2, n = 10 mice). a , Individual weight changes of mice in the indicated groups. b , Representative flow cytometry plots and quantification of IFN-γ + and IL-17a + CD4 + T-cell frequencies in the colon. c , Representative flow cytometry plots and quantification of Foxp3 + and Foxp3 <t>-</t> <t>Thy1.1</t> + OT-II cell frequencies among total CD4 + T cells in the indicated tissues. d , Representative flow cytometry plots and quantification of Rorγt + and Gata3 + cell frequencies among Foxp3 + OT-II cells in the indicated tissues. e , UMAP plots showing the indicated transcription factor activity scores across clusters. f , Venn diagram illustrating the overlap of up- and down-regulated DEGs between the indicated groups. DEGs were filtered using an adjusted p value < 0.0001 and log 2 fold change > 1. g , Gene regulatory networks and signature genes identified by scRNA-seq analysis. The two numbers in parentheses represent the specific values from the Venn diagram shown in Extended Data Fig. 12f (right). h , Schematic illustration of antigen-specific pTreg differentiation in vivo driven by TCR stimulation, TGM1–IL-2, and key transcription factors. Created in BioRender; Sun, Q. https://BioRender.com/2rbbpii (2026). Data are presented as mean ± s.e.m. The data in a–d are representative of two independent experiments. The statistics were obtained by unpaired Welch’s t-test (two-tailed) ( b and c ).
    Ot Ii Thy1 1 Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ot+ii+thy1+1+mice/pmc13190267-201-7-3?v=Jackson+Laboratory
    Average 86 stars, based on 1 article reviews
    ot ii thy1 1 mice - by Bioz Stars, 2026-06
    86/100 stars
    		  Buy from Supplier

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    a–d , Therapeutic effect of TGM1–IL-2 in DSS-induced colitis (PBS, n = 9 mice; TGM1–IL-2, n = 10 mice). a , Individual weight changes of mice in the indicated groups. b , Representative flow cytometry plots and quantification of IFN-γ + and IL-17a + CD4 + T-cell frequencies in the colon. c , Representative flow cytometry plots and quantification of Foxp3 + and Foxp3 - Thy1.1 + OT-II cell frequencies among total CD4 + T cells in the indicated tissues. d , Representative flow cytometry plots and quantification of Rorγt + and Gata3 + cell frequencies among Foxp3 + OT-II cells in the indicated tissues. e , UMAP plots showing the indicated transcription factor activity scores across clusters. f , Venn diagram illustrating the overlap of up- and down-regulated DEGs between the indicated groups. DEGs were filtered using an adjusted p value < 0.0001 and log 2 fold change > 1. g , Gene regulatory networks and signature genes identified by scRNA-seq analysis. The two numbers in parentheses represent the specific values from the Venn diagram shown in Extended Data Fig. 12f (right). h , Schematic illustration of antigen-specific pTreg differentiation in vivo driven by TCR stimulation, TGM1–IL-2, and key transcription factors. Created in BioRender; Sun, Q. https://BioRender.com/2rbbpii (2026). Data are presented as mean ± s.e.m. The data in a–d are representative of two independent experiments. The statistics were obtained by unpaired Welch’s t-test (two-tailed) ( b and c ).

    Journal: Nature

    Article Title: Facile induction of immune tolerance by an interleukin-2–TGFβ surrogate agonist

    doi: 10.1038/s41586-026-10208-0

    Figure Lengend Snippet: a–d , Therapeutic effect of TGM1–IL-2 in DSS-induced colitis (PBS, n = 9 mice; TGM1–IL-2, n = 10 mice). a , Individual weight changes of mice in the indicated groups. b , Representative flow cytometry plots and quantification of IFN-γ + and IL-17a + CD4 + T-cell frequencies in the colon. c , Representative flow cytometry plots and quantification of Foxp3 + and Foxp3 - Thy1.1 + OT-II cell frequencies among total CD4 + T cells in the indicated tissues. d , Representative flow cytometry plots and quantification of Rorγt + and Gata3 + cell frequencies among Foxp3 + OT-II cells in the indicated tissues. e , UMAP plots showing the indicated transcription factor activity scores across clusters. f , Venn diagram illustrating the overlap of up- and down-regulated DEGs between the indicated groups. DEGs were filtered using an adjusted p value < 0.0001 and log 2 fold change > 1. g , Gene regulatory networks and signature genes identified by scRNA-seq analysis. The two numbers in parentheses represent the specific values from the Venn diagram shown in Extended Data Fig. 12f (right). h , Schematic illustration of antigen-specific pTreg differentiation in vivo driven by TCR stimulation, TGM1–IL-2, and key transcription factors. Created in BioRender; Sun, Q. https://BioRender.com/2rbbpii (2026). Data are presented as mean ± s.e.m. The data in a–d are representative of two independent experiments. The statistics were obtained by unpaired Welch’s t-test (two-tailed) ( b and c ).

    Article Snippet: Foxp3 -GFP mice (IMSR_JAX:006772) were crossed with OT-II Thy1.1 mice.

    Techniques: Flow Cytometry, Activity Assay, In Vivo, Two Tailed Test